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We aimed to assess these factors in a cohort of HIV-negative people at risk of infection. We measured drug concentrations in plasma and dried blood spots in seroconverters and a random sample of seronegative participants. Statistical methods included Poisson models, comparison of proportions, and generalised estimating equations.

PrEP drug concentrations were higher among people of older age, with more schooling, who reported non-condom receptive anal intercourse, who had more sexual partners, and who had a history of syphilis or herpes. Interpretation: PrEP uptake was high when made available free of charge by experienced providers. The effect of PrEP is increased by greater uptake and adherence during periods of higher risk. Drug concentrations in dried blood spots are strongly correlated with protective benefit.

Conflicts of Interest:. PLA receives study drug and contract work from Gilead Sciences. MS received honoraria from Gilead for lecturing. JR is an employee of Gilead Sciences. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Search: Search. Advanced Clipboard. Display options Display options. Create file Cancel. citation Subject: 1 selected item: - PubMed.

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All HIV infected persons were offered participation in the study. s of visits and seroconversions at week 72 are higher due to participants who had been out of follow up who returned for a final visit. For those visits on PrEP, the incidence…. The incidence for the prior placebo group is depicted as a constant for reference.

The dotted lines represent the estimate bounded by one standard error. Dosing for each interval is estimated by pharmacokinetic modeling. The hazard ratios were adjusted for study site, age, ncRAI at entry and syphilis. Panel A is the proportion of study participants…. PrEP discontinuation occurs mainly in the first 24 weeks.

Each line reflects one participant. Seronegatives were frequency matched to cases by site on this time scale. See this image and copyright information in PMC. Landovitz RJ, et al. Lancet Infect Dis. Epub Jul PMID: No abstract available. Similar articles Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study.

Molina JM, et al. Lancet HIV. PMID: Retention, engagement, and adherence to pre-exposure prophylaxis for men who have sex with men and transgender women in PrEP Brasil: 48 week of a demonstration study. Grinsztejn B, et al. Epub Feb Liu AY, et al. Koechlin FM, et al. AIDS Behav. The future of PrEP among transgender women: the critical role of gender affirmation in research and clinical practices. Sevelius JM, et al. See all similar articles.

Gravett RM, et al. Online ahead of print. Foley JD, et al. Arch Sex Behav. Epub Jun 8. Chang XL, et al. Nat Commun. Baldwin A, et al. Epub Jun 1. Klein H, Washington TA. Klein H, et al. J Gay Lesbian Soc Serv. Epub Oct See all "Cited by" articles. Publication types Research Support, N. MeSH terms Adolescent Actions. Adult Actions. Cohort Studies Actions. Female Actions. Humans Actions.

Incidence Actions. Male Actions. Related information Cited in Books MedGen. Copy Download.

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